The Radio Room was founded in 2012 at their original location at 2845 N. Pleasantburg Drive. Then in Summer of 2017, Radio Room moved to their second location at 110 Poinsett Highway. They are now at their third location at 28 Liberty Lane, a 500 capacity room that can accommodate shows of all genres.

Some past acts that have played The Radio Room include: Bad Omens, Rainbow Kitten Surprise, Red Clay Strays, Shovels and Rope,  GZA, Slaughter to Prevail, The Mountain Goats, The Melvins, Black Flag, Modern English, Futurebirds, 49 Winchester, Flipturn, Charles Wesley Godwin, The Browning, Dexter and the Moonrocks, Thrown, Cupcakke,  Julia Wolf, Cracker, Violent Vira, Local H, Agnostic Front, H2O, Will Hoge, Nikki Lane, Starset, The Happy Fits, Agent Orange, Sister Hazel, Red Jumpsuit Apparatus, Beach Fossils, Paul Cauthen, American Aquarium, Dead Prez, Comeback Kid, Zao, Susto, My Life With The Thrill Kill Cult, Norma Jean, and many, many more.